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zapnometinib

CAS No. 303175-44-2

zapnometinib( 2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid | PD0184264 | ATR-002 )

Catalog No. M28604 CAS No. 303175-44-2

zapnometinib is a MEK inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 44 In Stock
5MG 38 In Stock
10MG 57 In Stock
25MG 69 In Stock
50MG 129 In Stock
100MG 253 In Stock
200MG 368 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    zapnometinib
  • Note
    Research use only, not for human use.
  • Brief Description
    zapnometinib is a MEK inhibitor.
  • Description
    zapnometinib is a MEK inhibitor.(In Vitro):Zapnometinib inhibits MEK, with IC50s of 30.96 nM, 357 nM, and 15 nM in cell free kinase assay, A549, MDCK cells and human PBMCs.Zapnometinib reduces the viral titers of the IV H1N1pdm09, H3N2.(In Vivo):Zapnometinib exhibits AUC values of 860.02 and 1953.68 μg h/mL in mice by i.v. or oral route, respectively.Zapnometinib reduces the lung virus titers and enhances survival of mice after lethal H1N1pdm09 infection.
  • In Vitro
    Western Blot Analysis Cell Line:human PBMCs Concentration:100 μM Incubation Time:4 h Result:Inhibited the Ionomycin (PMA/I)-increased pERK1/2.
  • In Vivo
    Animal Model:Female C57BL/6 mice (8 weeks; 21-24 g) were infected with H1N1pdm09 Dosage:8.4, 25, 75 mg/kg/day (2.8, 8.4, 25 mg/kg).Administration:P.o. three times a day Result:Significantly reduced the virus titer at the dose of either 75 mg/kg/day or 25 mg/kg/day.
  • Synonyms
    2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid | PD0184264 | ATR-002
  • Pathway
    Microbiology/Virology
  • Target
    Influenza Virus
  • Recptor
    Human Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    303175-44-2
  • Formula Weight
    409.55
  • Molecular Formula
    C13H7ClF2INO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (152.61 mM)
  • SMILES
    OC(c(c(Nc(ccc(I)c1)c1Cl)c1F)ccc1F)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kaur R, et al. Gluconic acid: an antifungal agent produced by Pseudomonas species in biological control of take-all. Phytochemistry. 2006 Mar;67(6):595-604.
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