Peramivir

Research use only, not for human use.

Peramivir (RWJ-270201, BCX-1812) is an inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B.

Peramivir (RWJ-270201, BCX-1812) is an inhibitor of influenza neuraminidase that prevents new viral particles from being released; an antiviral agent used to treat and prevent influenza A and influenza B.Influenza Approved.

Cell Cytotoxicity Assay Cell Line:RAW 264.7 Concentration:0.3125 μM, 0.625 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM, 20 μM, 40 μM Incubation Time:4 h Result:Showed no apparent toxicity in the peramivir-treated macrophages at concentrations up to 40 μM.

Animal Model: Cytokine storm syndrome model mice Dosage:20 mg/kg, 60 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Decreased 8 cytokines including TNF-a, IFN-a, IFN-γ, chemokines (MCP-1), GM-CSF, IL-1β, IL-6 and IL-12.Showed less inflammatory cell infiltrations, mild alveolar thickening and less bleeding points or congestion.Showed significant protective effects to the lung tissues.Animal Model:Immunocom promised murine models of infuenza B virus infection Dosage:75 mg/kg Administration:Intramuscular injection (i.m.)Result:Conferred complete protection against lethality, whether it was administered in one (1×), two (2×), or four (4×) doses, with maximum mean weight loss of 10% to 14%.Resulted in a trend of decreasing virus replication in the nasal cavities and lungs.

RWJ-270201 | BCX-1812

Microbiology/Virology

Influenza Virus

Influenza Virus

Infection

Influenza

330600-85-6

328.4072

C15H28N4O4

>98% (HPLC)

10 mM in DMSO

CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C

Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-, (1S,2S,3R,4R)-

(-20℃)

With Ice Pack

≥ 2 years