Cart
sales@molnova.com
Home - Products - Apoptosis - CFTR - GlyH-101

GlyH-101

CAS No. 328541-79-3

GlyH-101( GlyH 101 | GlyH101 )

Catalog No. M14072 CAS No. 328541-79-3

A potent CFTR inhibitor with Ki of 4.3 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 73 In Stock
5MG 65 In Stock
10MG 105 In Stock
25MG 221 In Stock
50MG 365 In Stock
100MG 548 In Stock
200MG 780 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    GlyH-101
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent CFTR inhibitor with Ki of 4.3 uM.
  • Description
    A potent CFTR inhibitor with Ki of 4.3 uM; rapidly and reversibly inhibited forskolin-induced hyperpolarization in nasal potential differences in mice; effectively reduces cholera toxin-induced intestinal fluid secretion in a closed-loop model of cholera.
  • In Vitro
    GlyH-101 (0-50 μM) shows antiproliferative activity in PCT and PS120 cells.GlyH-101 (0.5, 1, 5, 10 μM) inhibits CFTR-like current in a concentration-dependent manner in PCT cells.GlyH-101 (0.5, 1, 5, 10 μM) inhibits the VSORC current with IC50s of 5.38, 6.26 μM for PS120, PCT cells, respectively. Cell Viability Assay Cell Line:PCT, PS120 cells Concentration:0, 1, 5, 10, 20, 50 μM Incubation Time:24 h Result:Inhibited the cell growth in a dose-dependent manner.
  • In Vivo
    GlyH-101 (2.5 μg) reduces by about 80% cholera toxin-induced intestinal fluid secretion in mouse.
  • Synonyms
    GlyH 101 | GlyH101
  • Pathway
    Apoptosis
  • Target
    CFTR
  • Recptor
    CFTR
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    328541-79-3
  • Formula Weight
    493.1487
  • Molecular Formula
    C19H15Br2N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 58 mg/mL
  • SMILES
    O=C(N/N=C/C1=C(O)C(Br)=C(O)C(Br)=C1)CNC2=CC3=CC=CC=C3C=C2
  • Chemical Name
    Glycine, N-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Muanprasat C, et al. J Gen Physiol. 2004 Aug;124(2):125-37. 2. Norimatsu Y, et al. Mol Pharmacol. 2012 Dec;82(6):1042-55. 3. Barman PP, et al. Biochem Biophys Res Commun. 2011 Apr 29;408(1):12-7.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Bamocaftor

    Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function.

  • CFTR corrector 9

    CFTR Corrector 9, a cystic fibrosis transmembrane conductance regulator (CFTR) modulator, is employed in the research of cystic fibrosis (CF) and related CFTR-associated disorders .

  • CFTR(inh)-172

    CFTRinh-172 is a voltage-independent, selective CFTR inhibitor with Ki of 300 nM.

Sign In Join Free