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TDZD-8

CAS No. 327036-89-5

TDZD-8( TDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139 )

Catalog No. M14061 CAS No. 327036-89-5

A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 44 In Stock
5MG 40 In Stock
10MG 50 In Stock
25MG 73 In Stock
50MG 117 In Stock
100MG 184 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    TDZD-8
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM).
  • Description
    A potent, selective, non-ATP competitive GSK-3β inhibitor with IC50 of 2 uM; displays no activity against PKA, CK-2, PKC, and CDK1 (IC50>100 uM); reduces the colonic inflammation induced by TNBS in vivo, also prevents 6-OHDA-induced neuronal cell death.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    TDZD 8 | TDZD8 | GSK-3β Inhibitor I | NP 01139
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3β
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    327036-89-5
  • Formula Weight
    222.2636
  • Molecular Formula
    C10H10N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(N1CC2=CC=CC=C2)N(C)SC1=O
  • Chemical Name
    1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Martinez A, et al. J Med Chem. 2002 Mar 14;45(6):1292-9. 2. Whittle BJ, et al. Br J Pharmacol. 2006 Mar;147(5):575-82. 3. Dugo L, et al. Crit Care Med. 2005 Sep;33(9):1903-12.
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