Chloral hydrate

Research use only, not for human use.

Chloral Hydrate is a synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties.

Chloral Hydrate is a synthetic monohydrate of chloral with sedative, hypnotic, and anticonvulsive properties. Chloral hydrate is converted to the active compound trichloroethanol by hepatic alcohol dehydrogenase. The agent interacts with various neurotransmitter-operated ion channels, thereby enhancing gamma-aminobutyric acid (GABA)-A receptor mediated chloride currents and inhibiting amino acid receptor-activated ion currents. In addition, chloral hydrate enhances the agonistic effects of glycine receptors, inhibits AMPA-induced calcium influx in cortical neurons, and facilitates 5-HT 3 receptor-mediated currents in ganglionic neurons. Overall, this results in a depressive effect on the central nervous system.

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NSC 3210

Membrane Transporter/Ion Channel

GAT

GABAR

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302-17-0

165.4

C2H3Cl3O2

>98% (HPLC)

DMSO: 10 mM

OC(O)C(Cl)(Cl)Cl

2,2,2-Trichloroethane-1,1-diol

(-20℃)

With Ice Pack

≥ 2 years