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Mcl1-IN-2
CAS No. 292057-76-2
Mcl1-IN-2( Mcl1-IN-2 | Mcl1IN2 | Mcl1 IN 2 | Mcl1-inhibitor-2 | Mcl1 inhibitor 2 )
Catalog No. M13898 CAS No. 292057-76-2
Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 113 | In Stock |
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| 5MG | 113 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 315 | In Stock |
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| 50MG | 445 | In Stock |
|
| 100MG | 607 | In Stock |
|
| 200MG | 817 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMcl1-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionMcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
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DescriptionMcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
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In VitroIMB-XH1 (Compound 2) is a Mcl-1 inhibitor. IMB-XH is screened out with the IC50 value of 0.4637 μM at the concentration of 20 μg/mL. IMB-XH1 (20 μg/mL) can increase the sensitivity of E. coli BL21 (DE3) (pET-30a(+)-NDM-1) to ampicillinby more than 8 times. IMB-XHI may have a broad spectrum of metallo-β-lactamases (MBLs) inhibitory activity. The combination of IMB-XH1 and Meropenem (MEM) may have potentials to treat infections caused by metallo-β-lactamases-positive, carbapenem-resistant Gram-negative pathogens.
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In Vivo——
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SynonymsMcl1-IN-2 | Mcl1IN2 | Mcl1 IN 2 | Mcl1-inhibitor-2 | Mcl1 inhibitor 2
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PathwayAngiogenesis
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TargetBcl-2
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RecptorBcl-2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number292057-76-2
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Formula Weight333.4069
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Molecular FormulaC19H15N3OS
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESOC(C(N=CC=C1)=C1C=C2)=C2C(C3=CC=CS3)NC4=CC=CC=N4
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Chemical Name8-Quinolinol, 7-[(2-pyridinylamino)-2-thienylmethyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Richard DJ, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.
2. Zaneta Nikolovska-Coleska, et al. Discovery and characterization of new small-molecule inhibitors of Mcl-1 by high-throughput screening. AACR 2008.
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