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Mcl1-IN-2

CAS No. 292057-76-2

Mcl1-IN-2( Mcl1-IN-2 | Mcl1IN2 | Mcl1 IN 2 | Mcl1-inhibitor-2 | Mcl1 inhibitor 2 )

Catalog No. M13898 CAS No. 292057-76-2

Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Mcl1-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
  • Description
    Mcl1-IN-2 is an Mcl-1 inhibitor without a reported IC50 value.
  • In Vitro
    IMB-XH1 (Compound 2) is a Mcl-1 inhibitor. IMB-XH is screened out with the IC50 value of 0.4637 μM at the concentration of 20 μg/mL. IMB-XH1 (20 μg/mL) can increase the sensitivity of E. coli BL21 (DE3) (pET-30a(+)-NDM-1) to ampicillinby more than 8 times. IMB-XHI may have a broad spectrum of metallo-β-lactamases (MBLs) inhibitory activity. The combination of IMB-XH1 and Meropenem (MEM) may have potentials to treat infections caused by metallo-β-lactamases-positive, carbapenem-resistant Gram-negative pathogens.
  • In Vivo
    ——
  • Synonyms
    Mcl1-IN-2 | Mcl1IN2 | Mcl1 IN 2 | Mcl1-inhibitor-2 | Mcl1 inhibitor 2
  • Pathway
    Angiogenesis
  • Target
    Bcl-2
  • Recptor
    Bcl-2
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    292057-76-2
  • Formula Weight
    333.4069
  • Molecular Formula
    C19H15N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OC(C(N=CC=C1)=C1C=C2)=C2C(C3=CC=CS3)NC4=CC=CC=N4
  • Chemical Name
    8-Quinolinol, 7-[(2-pyridinylamino)-2-thienylmethyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Richard DJ, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. 2. Zaneta Nikolovska-Coleska, et al. Discovery and characterization of new small-molecule inhibitors of Mcl-1 by high-throughput screening. AACR 2008.
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