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Guanfacine
CAS No. 29110-47-2
Guanfacine( —— )
Catalog No. M13895 CAS No. 29110-47-2
A selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGuanfacine
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NoteResearch use only, not for human use.
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Brief DescriptionA selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone.
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DescriptionA selective α2A receptor agonist that can reduce peripheral sympathetic outflow and thus cansues a reduction in peripheral sympathetic tone; a sympatholytic agent used to treat hypertension and attention deficit hyperactivity disorder (ADHD).Hypertension Approved.
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In VitroGuanfacine increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level.Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks.
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In VivoGuanfacine enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task.Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC.Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing.
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Synonyms——
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PathwayGPCR/G Protein
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number29110-47-2
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Formula Weight246.0933
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Molecular FormulaC9H9Cl2N3O
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESC1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl
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Chemical NameBenzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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