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Senicapoc

CAS No. 289656-45-7

Senicapoc( ICA-17043 )

Catalog No. M13889 CAS No. 289656-45-7

A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Senicapoc
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM).
  • Description
    A potent, selective Gardos channel blocker that blocks Ca(2+)-induced rubidium flux from human RBCs (IC50=11 nM) and inhibits RBC dehydration (IC50=10-50 nM); shows greater potency and selectivity than Clotrimazole; increases RBC K(+) content and hematocrit (Hct), decreases corpuscular hemoglobin concentration (MCHC) in a transgenic mouse model of sickle cell disease (SAD); orally active.Other Indication Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ICA-17043
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Gardoschannel
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    289656-45-7
  • Formula Weight
    323.336
  • Molecular Formula
    C20H15F2NO
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
  • Chemical Name
    Benzeneacetamide, 4-fluoro-.alpha.-(4-fluorophenyl)-.alpha.-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stocker JW, et al. Blood. 2003 Mar 15;101(6):2412-8. 2. Ataga KI, et al. Blood. 2008 Apr 15;111(8):3991-7. 3. Minniti CP, et al. Br J Haematol. 2011 Dec;155(5):634-6.
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