Penfluridol

Research use only, not for human use.

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Cell Viability Assay Cell Line:Human AML cell lines, HL-60 (FLT3-WT), U937 (FLT3-WT), and MV4–11 (FLT3-ITD) Concentration:1.25, 2.5, 5, 10, 20, 40 μM Incubation Time:24, 48 h Result:Significantly reduced cell viability in a concentration-dependent manner.Apoptosis AnalysisCell Line:HL-60 and U937 cells harboring FLT3-WT Concentration:7.5?μM.Incubation Time:24?h Result:Induced concentration-dependent increases in the sub-G1 population. Triggered caspase-3 activation and corresponding PARP-1 cleavage in concentration- and time-dependent manners.Cell Autophagy Assay Cell Line:U937 and HL-60 cells Concentration:1.25, 2.5, 5, 7.5 μM Incubation Time:24?h Result:5 μM and 7.5?μM respectively induced dominant LC3B-II formation and caspase-3 activation in U937 and HL-60 cells.Western Blot Analysis Cell Line:BMDMs Concentration:1 μM Incubation Time:Pretream for 2 h Result:Obviously inhibited the increased phosphorylation levels of ERK, JNK, and p38 by TNFα (10 ng/mL; 15, 30, 60 min). RT-PCR Cell Line:BMDMs Concentration:1 μM Incubation Time:Pretream for 2 h Result:Inhibited TNFα-induced mRNA expressions of IL-1β, IL-6, IL-17, and NOS2.

Animal Model:DBA/1J male mice aged 10–12 weeks with type II chicken collagen-induced arthritis (CIA) model Dosage:10 mg/kg Administration:Daily oral gavage; from the 18th day after the first immunization Result: Inhibited inflammatory cell infiltration, suppressed pannus formation, and protected articular cartilage from damage. obviously decreased mRNA expressions of CXCL10 and MCP-1 in inflamed joints and statistically reduced production levels of inflammatory cytokines IL-1β and IL-6 in sera.

R-16341

GPCR/G Protein

Dopamine Receptor

Dopamine

Neurological Disease

——

26864-56-2

523.97

C28H27ClF5NO

>98% (HPLC)

Ethanol: 100 mg/mL (190.85 mM); DMSO: 100 mg/mL (190.85 mM)

OC1(C2=CC=C(Cl)C(C(F)(F)F)=C2)CCN(CCCC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC1

1-(4,4-bis(4-fluorophenyl)butyl)-4-(4-chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol

(-20℃)

With Ice Pack

≥ 2 years