UK-371804

Research use only, not for human use.

UK-371804 is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 10 nM.

UK-371804 is a potent and selective inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 10 nM; displays excellent selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin); inhibits exogenous uPA in human chronic wound fluid with IC50 of 0.89 uM; penetrates into pig wounds and inhibits exogenous uPA activity with no adverse effect on wound healing parameters in wound model following topical delivery.Ulcer Preclinical.

UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 μM). UK-371804 has its excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).

In a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. Concentrations of UK-371804 in the dermis are 41.8 μM.

UK371804 | UK 371804

Metabolic Enzyme/Protease

PAI-1

uPA

Other Indications

Ulcer

256477-09-5

385.82594

C14H16ClN5O4S

>98% (HPLC)

DMSO: 10 mg/mL

CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2/N=C(N)\N)=O)C(O)=O

Alanine, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-

(-20℃)

With Ice Pack

≥ 2 years