SEW2871( SEW2871 | SEW2871 | SEW2871. )

Catalog No. M13771 CAS No. 256414-75-2

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HNMR

HPLC

MSDS

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Product Name

SEW2871
Note

Research use only, not for human use.
Brief Description

Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
Description

Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.
In Vitro

——
In Vivo

Animal Model:IL-10–/– (interleukin (IL)-10 gene-deficient) mice, a murine model of Crohn's disease (CD)Dosage:20 mg/kg Administration:Gavage, once daily for 2 weeks Result:Ameliorated established colitis in IL-10–/– mice, associated with a reduction of serum amyloid A concentration, a decreased colon MPO concentration, a depletion of the peripheral CD4+CD45+ T cells and a reduction of the homing of T cells into colon LP. Suppressed typical cytokines of T helper type 1 (Th1) and Th17 cells and p-STAT-3 expression, and significantly decreased TNF-α, IFN-γ, IL-1β and IL-17A mRNA levels.
Synonyms

SEW2871 | SEW2871 | SEW2871.
Pathway

GPCR/G Protein
Target

S1P Receptor
Recptor

S1P1
Research Area

Cardiovascular Disease
Indication

——

CAS Number

256414-75-2
Formula Weight

440.36
Molecular Formula

C20H10F6N2OS
Purity

>98% (HPLC)
Solubility

DMSO > 10 mM
SMILES

FC(C1=CC(C2=NOC(C3=CC(C4=CC=CC=C4)=C(C(F)(F)F)S3)=N2)=CC=C1)(F)F
Chemical Name

5-(4-phenyl-5-(trifluoromethyl)thiophen-2-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole

1.Ni Q, et al. Int Immunopharmacol. 2015 May;26(1):37-42.

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