Cart
sales@molnova.com
G 573
CAS No. 22868-35-5
G 573( G573 )
Catalog No. M13632 CAS No. 22868-35-5
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF(V600E).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameG 573
-
NoteResearch use only, not for human use.
-
Brief DescriptionG 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF(V600E).
-
DescriptionG 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM; blocks MEK phosphorylation by BRAF(V600E), and stabilizes the RAF-MEK complex; inhibits the proliferation of A375 (BRAF V600E) with IC50 of 11 nM, 15-fold less potent for HCT116 (KRAS G13D).
-
In Vitro——
-
In Vivo——
-
SynonymsG573
-
PathwayMAPK/ERK Signaling
-
TargetMEK
-
RecptorMEK
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number22868-35-5
-
Formula Weight228.68
-
Molecular FormulaC13H9ClN2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESClC1=CC(C2=NC3=CC=CC=C3N2)=CC=C1
-
Chemical Name2-(3-Chlorophenyl)-1H-benzimidazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hatzivassiliou G, et al. Nature. 2013 Sep 12;501(7466):232-6.
molnova catalog
related products
-
RO-5126766
A potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1.
-
Binimetinib
Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.
-
PD318088
PD318088 is a potent, non-ATP competitive, allosteric MEK1/2 inhibitor.
