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Cinacalcet
CAS No. 226256-56-0
Cinacalcet( AMG 073 | AMG073 | AMG-073 )
Catalog No. M13617 CAS No. 226256-56-0
A calcimimetic agent that acts as an allosteric activator of CaSR.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 39 | Get Quote |
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| 25MG | 58 | Get Quote |
|
| 50MG | 72 | Get Quote |
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| 100MG | 132 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameCinacalcet
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NoteResearch use only, not for human use.
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Brief DescriptionA calcimimetic agent that acts as an allosteric activator of CaSR.
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DescriptionA calcimimetic agent that acts as an allosteric activator of CaSR; increases the concentration of cytoplasmic Ca(2+) in human embryonic kidney 293 cells expressing the human parathyroid CaR with EC50 of 51 nM; decreases PTH secretion from cultured bovine parathyroid cells with IC50 of 28 nM; is used for the treatment of tertiary hyperparathyroidism.Hyperparathyroidism Approved.
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In Vitro——
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In Vivo——
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SynonymsAMG 073 | AMG073 | AMG-073
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PathwayGPCR/G Protein
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TargetCaSR
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RecptorCaSR
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Research AreaEndocrinology
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IndicationHyperparathyroidism
Chemical Information
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CAS Number226256-56-0
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Formula Weight357.412
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Molecular FormulaC22H22F3N
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
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Chemical Name1-Naphthalenemethanamine, .alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, (.alpha.R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nemeth EF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):627-35.
2. Lindberg JS, et al. Kidney Int. 2003 Jan;63(1):248-54.
3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar;14(3):575-83.
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