RasGRP3 ligand 96( —— )

Catalog No. M13569 CAS No. 2229068-13-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RasGRP3 ligand 96
Note

Research use only, not for human use.
Brief Description

RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM.
Description

RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively; induces Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation in intact cells.
In Vitro

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In Vivo

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Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

——
Indication

——

CAS Number

2229068-13-5
Formula Weight

371.433
Molecular Formula

C21H25NO5
Purity

>98% (HPLC)
Solubility

——
SMILES

CC(C)(C)C(=O)OCC1(CC(=CC2=CN(C3=CC=CC=C32)C)C(=O)O1)CO
Chemical Name

(E)-(2-(Hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate

1. Ann J, et al. J Med Chem. 2018 Jul 3. doi: 10.1021/acs.jmedchem.8b00661.

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