Cart
sales@molnova.com
RasGRP3 ligand 96
CAS No. 2229068-13-5
RasGRP3 ligand 96( —— )
Catalog No. M13569 CAS No. 2229068-13-5
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRasGRP3 ligand 96
-
NoteResearch use only, not for human use.
-
Brief DescriptionRasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM.
-
DescriptionRasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively; induces Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation in intact cells.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
TargetRas
-
RecptorRas
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2229068-13-5
-
Formula Weight371.433
-
Molecular FormulaC21H25NO5
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C)(C)C(=O)OCC1(CC(=CC2=CN(C3=CC=CC=C32)C)C(=O)O1)CO
-
Chemical Name(E)-(2-(Hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ann J, et al. J Med Chem. 2018 Jul 3. doi: 10.1021/acs.jmedchem.8b00661.
molnova catalog
related products
-
ML-098
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1).
-
CID-1067700
CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).
-
SAH-SOS1A
KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
