dBRD9( dBRD 9 )

Catalog No. M13465 CAS No. 2170679-45-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

dBRD9
Note

Research use only, not for human use.
Brief Description

dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.
Description

dBRD9 is a PROTAC that bridge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex; exhibits markedly enhanced potency compared to parental ligands (10-100 fold).
In Vitro

Western Blot Analysis Cell Line:MOLM-13 cells.Concentration:0.5, 5, 50, 500 and 5000 nM.Incubation Time:4 h.Result:Reduced the expression of BRD9.
In Vivo

——
Synonyms

dBRD 9
Pathway

PROTACs
Target

PROTAC
Recptor

PROTAC
Research Area

——
Indication

——

CAS Number

2170679-45-3
Formula Weight

783.839
Molecular Formula

C40H45N7O10
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (127.58 mM)
SMILES

O=C(NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN(CC4=C(OC)C=C(C(C5=CC=NC=C65)=CN(C)C6=O)C=C4OC)C
Chemical Name

2-((2,6-dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide

1. Remillard D, et al. Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743.

Calculator

molnova catalog