Boc-Val-Cit-PAB-PNP( —— )

Catalog No. M22613 CAS No. 870487-10-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Boc-Val-Cit-PAB-PNP
Note

Research use only, not for human use.
Brief Description

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Description

Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
In Vivo

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Synonyms

——
Pathway

PROTACs
Target

PROTAC
Recptor

Cleavable
Research Area

——
Indication

——

CAS Number

870487-10-8
Formula Weight

644.67
Molecular Formula

C30H40N6O10
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (155.12 mM)
SMILES

CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CCCNC(N)=O)C(=O)Nc1ccc(COC(=O)Oc2ccc(cc2)[N+]([O-])=O)cc1
Chemical Name

——

1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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