KDM-IN-6( —— )

Catalog No. M13462 CAS No. 2169272-46-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

KDM-IN-6
Note

Research use only, not for human use.
Brief Description

KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively.
Description

KDM-IN-6 is a potent, highly selective and cell-active inhibitor of KDM2A/7A with IC50 of 0.16 and 0.19 uM,respectively; displays >75 fold selectivity towards KDM2A/7A versus other JmjC lysine demethylase; shows cytotoxicity towards HeLa and HAP1 cells with EC50 of 22 uM and 7.1 uM respectively.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Chromatin/Epigenetic
Target

Histone Demethylase
Recptor

Histone Demethylase
Research Area

——
Indication

——

CAS Number

2169272-46-0
Formula Weight

506.694
Molecular Formula

C33H38N4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (394.73 mM)
SMILES

CC(N([C@@H](C1=CN=CC(CCCCCCCN2CCCC2)=C1)[C@@]3(C4=CC=CC=C4)C#N)C5=C3C=CC=C5)=O
Chemical Name

(2S,3S)-1-acetyl-3-phenyl-2-(5-(7-(pyrrolidin-1-yl)heptyl)pyridin-3-yl)indoline-3-carbonitrile

1. Gerken P, et al. Angew Chem Int Ed Engl. 2017 Oct 4. doi: 10.1002/anie.201706788.

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