CIDD 0067106( CIDD0067106 )

Catalog No. M13435 CAS No. 2151865-39-1

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Product Name

CIDD 0067106
Note

Research use only, not for human use.
Brief Description

CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells.
Description

CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM); displays approximately 37.5- to 62.5-fold antiproliferative selectivity for MDA-MB-453 cells over others TNBC cells (MDA-MB-231 GI50=50 uM); inhibits the activity of the mTORC1 pathway.
In Vitro

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In Vivo

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Synonyms

CIDD0067106
Pathway

PI3K/Akt/mTOR signaling
Target

mTOR
Recptor

mTOR
Research Area

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Indication

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CAS Number

2151865-39-1
Formula Weight

483.99
Molecular Formula

C26H30ClN3O4
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(OC)[C@H]1N(CC2=CC=C(C3=NC=C(C4=CC=C(OC/C=C(C)/C)C=C4)O3)N=C2)CCC1
Chemical Name

(S)-Methyl-1-[(6-(5-(4-[(3-methylbut-2-en-1-yl)oxy]phenyl)-oxazol-2-yl)pyridin-3-yl)methyl]pyrrolidine-2-carboxylate

1. Robles AJ, et al. J Med Chem. 2017 Nov 3. doi: 10.1021/acs.jmedchem.7b01228.

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