GSK3004774( GSK 3004774 | GSK-3004774 )

Catalog No. M13412 CAS No. 2138814-32-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GSK3004774
Note

Research use only, not for human use.
Brief Description

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.
Description

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3; demonstrates low permeability and low portal drug concentrations and high luminal stability and high fecal drug recovery in vivo DMPK experiments.
In Vitro

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In Vivo

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Synonyms

GSK 3004774 | GSK-3004774
Pathway

GPCR/G Protein
Target

CaSR
Recptor

CaSR
Research Area

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Indication

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CAS Number

2138814-32-9
Formula Weight

528.697
Molecular Formula

C32H40N4O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (189.15 mM)
SMILES

CC(C1=CC=CC2=CC=CC=C21)NC3CCN(C3)C4=CC=C(C=C4)C(=O)NCCCN5CCC(CC5)C(=O)O
Chemical Name

1-(3-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)benzamido)propyl)piperidine-4-carboxylic acid

1.? Sparks?SM,?et?al.?Bioorg?Med?Chem?Lett.?2017?Oct?15;27(20):4673-4677.

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