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FXR-sHE modulator 57

CAS No. 2129523-23-3

FXR-sHE modulator 57( —— )

Catalog No. M13389 CAS No. 2129523-23-3

A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FXR-sHE modulator 57
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
  • Description
    A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4); demonstrates antisteatotic and antifibrotic effects and potential for nonalcoholic steatohepatitis (NASH) management with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    FXR
  • Recptor
    FXR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2129523-23-3
  • Formula Weight
    394.914
  • Molecular Formula
    C19H23ClN2O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-(tert-Butyl)-N-(2-chloro-4-(methylsulfonamido)benzyl)-benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schmidt J, et al. J Med Chem. 2017 Sep 28;60(18):7703-7724.
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