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FXR-sHE modulator 57
CAS No. 2129523-23-3
FXR-sHE modulator 57( —— )
Catalog No. M13389 CAS No. 2129523-23-3
A potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameFXR-sHE modulator 57
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4).
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DescriptionA potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4); demonstrates antisteatotic and antifibrotic effects and potential for nonalcoholic steatohepatitis (NASH) management with low toxicity, and pilot in vivo data revealed favorable pharmacokinetics.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetFXR
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RecptorFXR
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Research Area——
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Indication——
Chemical Information
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CAS Number2129523-23-3
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Formula Weight394.914
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Molecular FormulaC19H23ClN2O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-(tert-Butyl)-N-(2-chloro-4-(methylsulfonamido)benzyl)-benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Chenodeoxycholic Aci...
Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.
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Tauro-Obeticholic ac...
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
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Ursodeoxycholic acid...
Ursodeoxycholic acid sodium is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors,
