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Home - Products - GPCR/G Protein - Chemokine Receptor - SB 265610

SB 265610

CAS No. 211096-49-0

SB 265610( SB265610 | SB-265610 )

Catalog No. M13354 CAS No. 211096-49-0

A potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SB 265610
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM.
  • Description
    A potent, selective, reversible CXCR2 antagonist with with Kd of 3.48 nM; inhibits protein nitration induced by hyperoxia, reduces radical formation in hyperoxia-exposed newborn rat lung; also induces G1 arrest, ans shows anti-proliferative activity in in IL8-rich tumor microenvironments.
  • In Vitro
    ——
  • In Vivo
    Animal Model:MMTV-PyVmT/Tgfbr2MGKO and MMTV-PyVmT/Tgfbr2flox/flox tumors from donor mice Dosage:2 mg/kg/day Administration:Intraperitoneal injection; daily; for two weeks Result:Significantly inhibited the recruitment of Gr-1+CD11b+ cells to the mammary adenocarcinoma.
  • Synonyms
    SB265610 | SB-265610
  • Pathway
    GPCR/G Protein
  • Target
    Chemokine Receptor
  • Recptor
    Chemokine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    211096-49-0
  • Formula Weight
    357.16
  • Molecular Formula
    C14H9BrN6O
  • Purity
    >98% (HPLC)
  • Solubility
    100 mM in DMSO
  • SMILES
    O=C(NC1=C2N=NNC2=C(C#N)C=C1)NC3=CC=CC=C3Br
  • Chemical Name
    N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. de Kruijf P, et al. J Pharmacol Exp Ther. 2009 May;329(2):783-90. 2. Bradley ME, et al. Br J Pharmacol. 2009 Sep;158(1):328-38. 3. de Kruijf P, et al. Mol Pharmacol. 2011 Dec;80(6):1108-18. 4. Goda AE, et al. Anticancer Res. 2015 Jun;35(6):3235-43.
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