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GSK-2239633
CAS No. 2181665-31-4
GSK-2239633( GSK2239633 )
Catalog No. M13483 CAS No. 2181665-31-4
GSK-2239633 is a potent, selective, allosteric CCR4 antagonist with pIC50 of 7.96.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 963 | Get Quote |
|
| 50MG | 1962 | Get Quote |
|
| 100MG | 2520 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGSK-2239633
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NoteResearch use only, not for human use.
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Brief DescriptionGSK-2239633 is a potent, selective, allosteric CCR4 antagonist with pIC50 of 7.96.
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DescriptionGSK-2239633 is a potent, selective, allosteric CCR4 antagonist with pIC50 of 7.96; also inhibits TARC-induced increases in the F-actin content of isolated human CD4+ CCR4+ T-cells with pA2 of 7.1.Asthma Phase 1 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGSK2239633
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PathwayGPCR/G Protein
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TargetChemokine Receptor
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RecptorChemokine Receptor
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Research AreaInflammation/Immunology
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IndicationAsthma
Chemical Information
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CAS Number2181665-31-4
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Formula Weight506.976
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Molecular FormulaC21H19ClN4O5S2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=CC(CN2N=C(NS(=O)(C3=CC=C(Cl)S3)=O)C4=C2C=CC=C4OC)=C1)CO
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Chemical NameN-(3-((3-((5-chlorothiophene)-2-sulfonamido)-4-methoxy-1H-indazol-1-yl)methyl)phenyl)-2-hydroxyacetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cahn A, et al. BMC Pharmacol Toxicol. 2013 Feb 28;14:14.
2. Procopiou PA, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2730-3.
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