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PI3Kα-IN-5
CAS No. 2101744-13-0
PI3Kα-IN-5( —— )
Catalog No. M13338 CAS No. 2101744-13-0
PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePI3Kα-IN-5
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NoteResearch use only, not for human use.
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Brief DescriptionPI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively.
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DescriptionPI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ; displays high potency and selectivity, and suitable physiochemical and pharmacokinetic properties for oral administration; shows good inhibition of tumour growth (86% tumour growth inhibition at 50 mg/kg twice daily orally) in the MCF7 xenograft model in mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number2101744-13-0
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Formula Weight363.385
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Molecular FormulaC17H17N9O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-(3-amino-6-(imidazo[1,2-a]pyridin-3-yl)-5-methylpyrazin-2-yl)-N,1-dimethyl-1H-1,2,4-triazole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Barlaam B, et al. Bioorg Med Chem Lett. 2017 Jul 1;27(13):3030-3035.
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