Cart
sales@molnova.com
Home - Products - MAPK/ERK Signaling - p38 MAPK - VX-745

VX-745

CAS No. 209410-46-8

VX-745( VX 745 | VX745 | Neflamapimod )

Catalog No. M13290 CAS No. 209410-46-8

A potent and selective p38α kinase inhibitor with IC50 of 9 nM; shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 In Stock
10MG 63 In Stock
25MG 115 In Stock
50MG 195 In Stock
100MG 291 In Stock
200MG 434 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    VX-745
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective p38α kinase inhibitor with IC50 of 9 nM; shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6).
  • Description
    A potent and selective p38α kinase inhibitor with IC50 of 9 nM; shows 20-fold selectivity for p38α over p38β (Ki=220 nM) and no significant inhibition for MAP kinases (with the exception of MKK6); exhibits inhibition of PBMC IL-1β and TNFα IC50 of 45 and 51 nM, respectively; possesses favorable PK profile, and demonstrates good in vivo activity in models of inflammation.Alzheimer's Disease Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    VX 745 | VX745 | Neflamapimod
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    p38α|p38β
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    209410-46-8
  • Formula Weight
    436.2621
  • Molecular Formula
    C19H9Cl2F2N3OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 13.08 mg/mL (Need ultrasonic)
  • SMILES
    O=C1C(C2=C(Cl)C=CC=C2Cl)=C3C=CC(SC4=CC=C(F)C=C4F)=NN3C=N1
  • Chemical Name
    6H-Pyrimido[1,6-b]pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Duffy JP, et al. ACS Med Chem Lett. 2011 Jul 28;2(10):758-63. 2. McGuire VA, et al. Mol Cell Biol. 2013 Nov;33(21):4152-65. 3. Alam JJ. J Alzheimers Dis. 2015;48(1):219-27.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Antimicrobial agent-...

    Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment of cataracts, ulcerative colitis, meningitis and Kawasaki's disease and Parkinson's disease.

  • APS6-45

    APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.

  • HS220

    HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival.

Sign In Join Free