HJB-97

Research use only, not for human use.

A potent BET bromodomian inhibitor with IC50 of 3-7 nM for BRD2/3/4 BD1 and BD2.

A potent BET bromodomian inhibitor with IC50 of 3-7 nM for BRD2/3/4 BD1 and BD2.

HJB97 is a highly potent and efficacious bomodomain and extra terminal (BET) inhibitor with IC50s of 3.1 nM (BRD2 BD1), 3.9 nM (BRD2 BD2), 6.6 nM (BRD3 BD1), 1.9 nM (BRD3 BD2), 7.0 nM (BRD4 BD1), 7.0 nM (BRD4 BD2).HJB97 (10-1000 nM, 4 days) potently inhibits cell growth in RS4;11 and MOLM-13 acute leukemia cell lines with IC50s of 24.1 nM and 25.6 nM.HJB97 can effectively down-regulate the level of c-Myc at concentrations of 300-1000 nM in the RS4;11 cell line (treated for 24 h). Cell Viability Assay Cell Line:The human acute leukemia RS4;11 cell line; The human acute leukemia MOLM-13 cell line Concentration:10-1000 nM Incubation Time:4 days Result:Achieved IC50s value of 24.1±5.3 nM and 25.6±1.9 nM in inhibition of the RS4;11 cell and MOLM-13 cell growth.Western Blot Analysis Cell Line:RS4;11 cells Concentration:30, 100, 300, 1000 nM Incubation Time:24 h Result:Down-regulated the level of c-Myc but at concentrations of 300-1000 nM in the RS4;11 cell line.

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HJB 97 | HJB97

Chromatin/Epigenetic

Bromodomain

Bromodomain

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2093391-24-1

500.563

C26H28N8O3

>98% (HPLC)

DMSO : 30 mg/mL 59.93 mM;H2O : < 0.1 mg/mL

O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NC

4-((3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-N-methyl-9H-pyrimido[4,5-b]indole-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years