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BRD3731
CAS No. 2056262-08-7
BRD3731( BRD-3731 | BRD 3731 )
Catalog No. M13196 CAS No. 2056262-08-7
BRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 590 | Get Quote |
|
| 50MG | 1341 | Get Quote |
|
| 100MG | 1935 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBRD3731
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NoteResearch use only, not for human use.
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Brief DescriptionBRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM).
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DescriptionBRD3731 is a potent, selective GSK3β inhibitor with IC50 of 15 nM, 14-fold selectivity for GSK3β over GSK3α (IC50=215 nM); displays excellent selectivity in a penal of 311 kinases, displays reduced potency toward the GSK3β mutant (D133E) with IC50 of 53 nM; induces β-catenin stabilization starting at 20 uM in the HL-60 AML cell line, decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation, resulting in increased β-catenin.
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In Vitro——
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In Vivo——
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SynonymsBRD-3731 | BRD 3731
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3
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Research Area——
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Indication——
Chemical Information
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CAS Number2056262-08-7
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Formula Weight377.532
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Molecular FormulaC24H31N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (529.77 mM)
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SMILES——
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Chemical Name(R)-4,7,7-trimethyl-3-neopentyl-4-phenyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7;10(431). pii: eaam8460.
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