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Indirubin-3'-monoxime
CAS No. 160807-49-8
Indirubin-3'-monoxime( —— )
Catalog No. M12312 CAS No. 160807-49-8
A potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 52 | In Stock |
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| 2MG | 30 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 77 | In Stock |
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| 25MG | 160 | In Stock |
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| 50MG | 241 | In Stock |
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| 100MG | 359 | In Stock |
|
| 200MG | 527 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIndirubin-3'-monoxime
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NoteResearch use only, not for human use.
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Brief DescriptionA potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo.
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DescriptionA potent GSK3β inhibitor with IC50 of 22 nM; prevents tau phosphorylation both in vitro and in vivo; also inhibits CDKs at higher concentrations, including Cdk1/cyclin B (IC50=180 nM), Cdk2/cyclin A (IC50~500 nM), Cdk2/cyclin E (IC50=250nM), Cdk4/cyclin D1 (IC50=3.3 uM) and Cdk5/p35 (IC50=100 nM); reversibly inhibits the proliferation of many cells types, arresting cycling in the G2/M phase.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3β|CDK1/cyclinB|CDK5/p25|Cdk2/cyclinE
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number160807-49-8
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Formula Weight277.2774
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Molecular FormulaC16H11N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 37 mg/mL
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SMILESC1=CC=C2C(=C1)C(=C(N2)O)C3=C(C4=CC=CC=C4N3)N=O
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Chemical Name2H-Indol-2-one, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Leclerc S, et al. J Biol Chem. 2001 Jan 5;276(1):251-60.
2. Hoessel R, et al. Nat Cell Biol. 1999 May;1(1):60-7.
3. Damiens E, et al. Oncogene. 2001 Jun 28;20(29):3786-97.
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