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Sulfaphenazole
CAS No. 526-08-9
Sulfaphenazole( BRN-0308518 | Sulfaphenazole | Firmazolo | Inamil )
Catalog No. M18732 CAS No. 526-08-9
Sulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 100MG | 47 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSulfaphenazole
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NoteResearch use only, not for human use.
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Brief DescriptionSulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).
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DescriptionSulfaphenazole is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.
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In VitroApoptosis Analysis Cell Line:661W cells Concentration:10 μM Incubation Time:For 1 h at 37 °C followed by light exposure for 2-3 h Result:The numbers of light-induced apoptotic and necrotic cells were decreased by 33 and 44%, respectively.
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In VivoAnimal Model:Diabetic male mice (db/db strain) Dosage:5.13 mg/kg Administration:Intraperitoneal injections; daily; for 8 weeks Result:Although sulfaphenazole did not change endothelium-dependent vasodilation in control mice, it restored endothelium-mediated relaxation in db/db mice.
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SynonymsBRN-0308518 | Sulfaphenazole | Firmazolo | Inamil
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorCYP2C9
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number526-08-9
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Formula Weight314.36
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Molecular FormulaC15H14N4O2S
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 100 mg/mL; 318.11 mM
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SMILESNc1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccc1
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Chemical Name4-amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Annah Mancy, et al. Biochemistry, 1996, 35(50):16205.
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