SR12343

Research use only, not for human use.

SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation.

SR12343 (SR-12343) is a novel NF-κB essential modulator (NEMO)-binding domain (NBD) mimetic for inhibiting IKK/NF-κB activation, inhibits TNF-α-mediated NF-κB activation with IC50 of 11.34 uM in luciferase assays; inhibits lipopolysaccharide (LPS)-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, significantly inhibits COX-2, IL-6, and iNOS expression at 50 uM in cellular assays; suppresses LPS-induced acute pulmonary inflammation, alleviates necrosis and muscle degeneration in mdx mice without overt liver toxicity.

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SR 12343 | SR-12343

Apoptosis

NF-κB

NF-κB

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2055101-86-3

368.659

C15H15BrClN3O

>98% (HPLC)

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C1=CC(=CC(=C1)Br)CCNC(=O)CNC2=NC=C(C=C2)Cl

N-(3-bromophenethyl)-2-((5-chloropyridin-2-yl)amino)acetamide

(-20℃)

With Ice Pack

≥ 2 years