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14-Deoxy-1112-didehydroandrographolide
CAS No. 42895-58-9
14-Deoxy-1112-didehydroandrographolide( 14-dehydro Andrographolide | AP10 )
Catalog No. M21667 CAS No. 42895-58-9
14-Deoxy-1112-didehydroandrographolide has hypotensive anti-inflammatory anti-asthma and anti-cancer actions. It can inhibit NF-κB activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 141 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 375 | In Stock |
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| 50MG | 548 | In Stock |
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| 100MG | 760 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product Name14-Deoxy-1112-didehydroandrographolide
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NoteResearch use only, not for human use.
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Brief Description14-Deoxy-1112-didehydroandrographolide has hypotensive anti-inflammatory anti-asthma and anti-cancer actions. It can inhibit NF-κB activation.
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Description14-Deoxy-1112-didehydroandrographolide has hypotensive anti-inflammatory anti-asthma and anti-cancer actions. It can inhibit NF-κB activation.
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In Vitro14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.
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In Vivo14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.
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Synonyms14-dehydro Andrographolide | AP10
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number42895-58-9
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Formula Weight332.43
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Molecular FormulaC20H27O4
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Purity>98% (HPLC)
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SolubilityDMF: 100 mg/mL (300.82 mM; Need ultrasonic)
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SMILESO=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@](O)CC[C@@]23C)=C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Guan SP et al. Protective role of 14-deoxy-1112-didehydroandrographolide a noncytotoxic analogue ofandrographolide in allergic airway inflammation. J Nat Prod. 2011 Jun 24;74(6):1484-90.
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