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JQ-1 carboxylic acid
CAS No. 202592-23-2
JQ-1 carboxylic acid( +)-JQ-1 carboxylic acid )
Catalog No. M13156 CAS No. 202592-23-2
JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 67 | In Stock |
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| 5MG | 61 | In Stock |
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| 10MG | 76 | In Stock |
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| 25MG | 117 | In Stock |
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| 50MG | 152 | In Stock |
|
| 100MG | 230 | In Stock |
|
| 200MG | 346 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJQ-1 carboxylic acid
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NoteResearch use only, not for human use.
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Brief DescriptionJQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins.
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DescriptionJQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones; a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.
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In Vitro——
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In Vivo——
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Synonyms+)-JQ-1 carboxylic acid
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number202592-23-2
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Formula Weight400.8819
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Molecular FormulaC19H17ClN4O2S
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILESO=C(O)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1
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Chemical Name6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.
2. Mertz JA, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.
3. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33.
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