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Home - Products - Chromatin/Epigenetic - HMTase - PF-06855800

PF-06855800

CAS No. 1989620-04-3

PF-06855800( PF06855800 )

Catalog No. M13110 CAS No. 1989620-04-3

PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PF-06855800
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM.
  • Description
    PF-06855800 (PF06855800) is a potent, selective, SAM competitive, BBB-penetrant, orally active inhibitor of protein arginine methyltransferase PRMT5 with Ki of 0.02 nM; demonstrates antiproliferative activity in Z-138 cancer cells with IC50 of 1 nM, also shows anti-tumor activity in Z-138 mice xenograft models.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF06855800
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1989620-04-3
  • Formula Weight
    392.811
  • Molecular Formula
    C19H18ClFN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (316.63 mM)
  • SMILES
    NC1=C2C(N([C@H]3[C@@H]([C@@H]([C@@H]([C@@H](C4=CC=C(Cl)C(F)=C4)O)O3)O)O)C=C2)=NC=N1
  • Chemical Name
    (2R,3S,4R,5R)-2-((R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl)-5-(4-methyl-1H-pyrrolo[3,2-c]pyridin-1-yl)tetrahydrofuran-3,4-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Indrawan J. Mcalpine, et al. Abstract 4857: Discovery of PF-06855800, a SAM competitive PRMT5 inhibitor with potent antitumor activity. DOI: 10.1158/1538-7445.AM2018-4857. AACR 2018.
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