Cortexolone 17 alpha-propionate

CAS No. 19608-29-8

Cortexolone 17 alpha-propionate( Cortexolone 17α-propionate | CB-03-01 | Clascoterone )

Catalog No. M13075 CAS No. 19608-29-8

Cortexolone 17 alpha-propionate (CB-03-01, Clascoterone) is a topical and peripherally selective androgen antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 28 In Stock
25MG 41 In Stock
50MG 54 In Stock
100MG 86 In Stock
200MG 127 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Cortexolone 17 alpha-propionate
  • Note
    Research use only, not for human use.
  • Brief Description
    Cortexolone 17 alpha-propionate (CB-03-01, Clascoterone) is a topical and peripherally selective androgen antagonist.
  • Description
    Cortexolone 17 alpha-propionate (CB-03-01, Clascoterone) is a topical and peripherally selective androgen antagonist, displays a strong local antiandrogenic activity in hamster's flank organ test, does not exhibit antiandrogenic activity after subcutaneous injection in vivo.Other Indication Phase 3 Clinical(In Vivo):Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
  • In Vitro
    ——
  • In Vivo
    Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.
  • Synonyms
    Cortexolone 17α-propionate | CB-03-01 | Clascoterone
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    AndrogenReceptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    19608-29-8
  • Formula Weight
    402.53
  • Molecular Formula
    C24H34O5
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CCC(O[C@]1(C(CO)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
  • Chemical Name
    Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Celasco G, et al. Arzneimittelforschung. 2004;54(12):881-6. 2. Trifu V, et al. Br J Dermatol. 2011 Jul;165(1):177-83.
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