Cart
sales@molnova.com
dBET6
CAS No. 1950634-92-0
dBET6( dBET 6 )
Catalog No. M13051 CAS No. 1950634-92-0
dBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 151 | In Stock |
|
| 5MG | 93 | In Stock |
|
| 10MG | 163 | In Stock |
|
| 25MG | 307 | In Stock |
|
| 50MG | 482 | In Stock |
|
| 100MG | 697 | In Stock |
|
| 200MG | 879 | In Stock |
|
| 500MG | 1283 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamedBET6
-
NoteResearch use only, not for human use.
-
Brief DescriptiondBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
-
DescriptiondBET6 is a highly cell-permeable, optimized chemical degrader of BET bromodomain BED4, does not directly affect CDK9 localization.
-
In VitrodBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4.
-
In VivodBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL.
-
SynonymsdBET 6
-
PathwayPROTACs
-
TargetPROTAC
-
RecptorBET
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1950634-92-0
-
Formula Weight841.381
-
Molecular FormulaC42H45ClN8O7S
-
Purity>98% (HPLC)
-
SolubilityDMSO: 10 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
-
SMILESO=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
-
Chemical Name6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide, 4-(4-chlorophenyl)-N-[8-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]octyl]-2,3,9-trimethyl-, (6S)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Winter GE, et al. Mol Cell. 2017 Jul 6;67(1):5-18.e19.
2. Cancer Discov. 2017 Aug;7(8):794.
molnova catalog
related products
-
CM11
A homo-PROTAC, bivalent small-molecule dimerizer of the VHL E3 ubiquitin ligase to induce self-degradation; induces potent, rapid and proteasome-dependent self-degradation of VHL in different cell lines.
-
FKBP12 PROTAC dTAG-1...
FKBP12 PROTAC dTAG-13 (dTAG-13) is an in vivo-active heterobifunctional adation tag (dTAG) small molecule that engage FKBP12F36V and CRBN.
-
BI-3663
BI-3663 (BI 3663) is a cereblon-based degrader (PROTAC) of Focal adhesion tyrosine kinase (PTK2/FAK) with a median DC50 of 30 nM to >80% across a panel of eleven HCC cell lines.
