PI4KIIIbeta-IN-10( —— )

Catalog No. M12918 CAS No. 1881233-39-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI4KIIIbeta-IN-10
Note

Research use only, not for human use.
Brief Description

A potent and selective type III phosphatidylinositol 4-kinase (PI4KIIIβ) inhibitor with IC50 of 3.6 nM.
Description

A potent and selective type III phosphatidylinositol 4-kinase (PI4KIIIβ) inhibitor with IC50 of 3.6 nM; displays >200-fold selectivity over class I and class III PI3Ks; shows antiviral activity against hepatitis C virus with IC50 of 1.3 uM, with low cytotoxicity (CC50>32 uM).
In Vitro

PI4KIIIbeta-IN-10 (Compound 10) is a potent PI4KIIIβ inhibitor with very minor off-target inhibition of PI4KIIIβ related lipid kinases. PI4KIIIbeta-IN-10 shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~10 μM), and PI4KIIIα (~3 μM), and <20% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ.
In Vivo

——
Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

PI4K
Recptor

PI4K
Research Area

Inflammation/Immunology
Indication

——

CAS Number

1881233-39-1
Formula Weight

475.581
Molecular Formula

C22H25N3O5S2
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 30 mg/mL
SMILES

CC1=C(SC(=N1)NC(=O)C(C)(C)C)C2=CC(=C(C=C2)OC)S(=O)(=O)NC3=CC=C(C=C3)O
Chemical Name

N-(5-(3-(N-(4-hydroxyphenyl)sulfamoyl)-4-methoxyphenyl)-4-methylthiazol-2-yl)pivalamide

1. Rutaganira FU, et al. J Med Chem. 2016 Mar 10;59(5):1830-9.

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