PI4KIIIβ-IN-9( —— )

Catalog No. M11813 CAS No. 1429624-84-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PI4KIIIβ-IN-9
Note

Research use only, not for human use.
Brief Description

PI4KIIIβ-IN-9 is a potent and selective inhibitor of PI4KIIIβ (IC50=7 nM).
Description

PI4KIIIβ-IN-9 is a potent and selective inhibitor of PI4KIIIβ (IC50=7 nM); displays >1000-fold selectivity over class I and class III PI3Ks; A KN-93 derivative with improved selectivity.
In Vitro

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 μM), PI3Kα (~2 μM), and PI4KIIIα (~2.6 μM) and <50% inhibition at concentrations up to 20 μM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ.
In Vivo

——
Synonyms

——
Pathway

PI3K/Akt/mTOR signaling
Target

PI4K
Recptor

PI4K
Research Area

Cancer
Indication

——

CAS Number

1429624-84-9
Formula Weight

487.5917
Molecular Formula

C23H25N3O5S2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=C(SC(=N1)NC(=O)C2CCCC2)C3=CC(=C(C=C3)OC)S(=O)(=O)NC4=CC=C(C=C4)O
Chemical Name

Cyclopentanecarboxamide, N-[5-[3-[[(4-hydroxyphenyl)amino]sulfonyl]-4-methoxyphenyl]-4-methyl-2-thiazolyl]-

1. Rutaganira FU, et al. J Med Chem. 2016 Mar 10;59(5):1830-9.

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