Cart
sales@molnova.com
DC661
CAS No. 1872387-43-3
DC661( DC-661 | DC 661 )
Catalog No. M12900 CAS No. 1872387-43-3
DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 230 | In Stock |
|
| 2MG | 102 | In Stock |
|
| 5MG | 188 | In Stock |
|
| 10MG | 319 | In Stock |
|
| 25MG | 544 | In Stock |
|
| 50MG | 764 | In Stock |
|
| 100MG | 1051 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDC661
-
NoteResearch use only, not for human use.
-
Brief DescriptionDC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
-
DescriptionDC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1); inhibits autophagy and causes significant impairment of tumor growth.
-
In VitroDC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells.
-
In Vivo——
-
SynonymsDC-661 | DC 661
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorAutophagy
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1872387-43-3
-
Formula Weight550.612
-
Molecular FormulaC33H41Cl2N3
-
Purity>98% (HPLC)
-
SolubilityDMSO : 62.5 mg/mL 113.11 mM;H2O : < 0.1 mg/mL
-
SMILESCN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
-
Chemical NameN1-(6-chloronaphthalen-1-yl)-N6-(6-((6-chloronaphthalen-1-yl)amino)hexyl)-N6-methylhexane-1,6-diamine
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Rebecca VW, et al. Cancer Discov. 2018 Nov 15. pii: CD-18-0706. doi: 10.1158/2159-8290.CD-18-0706.
molnova catalog
related products
-
AUTEN-67
A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
-
MRT68921 HCl
MRT68921 hydrochloride is a potent inhibitor of both ULK1 and ULK2 (IC50s: 2.9 and 1.1 nM respectively).
-
Thymosin β4 acetate(...
Thymosin β4 (Tβ4) is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration.
