DC661( DC-661 | DC 661 )

Catalog No. M12900 CAS No. 1872387-43-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

DC661
Note

Research use only, not for human use.
Brief Description

DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1).
Description

DC661 (DC-661) is a novel dimeric chloroquine (CQ) that is capable of deacidifying the lysosome and inhibiting autophagy significantly better than HCQ, targets palmitoyl-protein thioesterase 1 (PPT1); inhibits autophagy and causes significant impairment of tumor growth.
In Vitro

DC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells.
In Vivo

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Synonyms

DC-661 | DC 661
Pathway

Autophagy
Target

Autophagy
Recptor

Autophagy
Research Area

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Indication

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CAS Number

1872387-43-3
Formula Weight

550.612
Molecular Formula

C33H41Cl2N3
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 113.11 mM;H2O : < 0.1 mg/mL
SMILES

CN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
Chemical Name

N1-(6-chloronaphthalen-1-yl)-N6-(6-((6-chloronaphthalen-1-yl)amino)hexyl)-N6-methylhexane-1,6-diamine

1. Rebecca VW, et al. Cancer Discov. 2018 Nov 15. pii: CD-18-0706. doi: 10.1158/2159-8290.CD-18-0706.

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