LLY-507( LLY-507 | LLY 507 | LLY507 )

Catalog No. M12702 CAS No. 1793053-37-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

LLY-507
Note

Research use only, not for human use.
Brief Description

A potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM).
Description

A potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM); displays >100-fold selective over a broad range of methyltransferase and non-methyltransferase targets; inhibits SMYD2-mediated methylation of p53 Lys370 and suppresses proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner (IC50=1.5-6 uM).
In Vitro

Cell Proliferation Assay Cell Line:ESCC, HCC, breast cancer cell lines Concentration:0-20 μM Incubation Time:3 days, 7 days Result:Inhibited tumor cell proliferation.Western Blot Analysis Cell Line:HEK293 cells Concentration:0.03 μM, 0.07 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM Incubation Time:28 hours Result:Inhibited SMYD2-mediated methylation of p53 Lys370 in cells.
In Vivo

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Synonyms

LLY-507 | LLY 507 | LLY507
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

SMYD2
Research Area

Cancer
Indication

——

CAS Number

1793053-37-8
Formula Weight

574.7583
Molecular Formula

C36H42N6O
Purity

>98% (HPLC)
Solubility

DMSO: 15 mg/mL
SMILES

O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6
Chemical Name

[1,1'-Biphenyl]-3-carboxamide, 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-

1. Nguyen H, et al. J Biol Chem. 2015 May 29;290(22):13641-53. 2. Olsen JB, et al. Mol Cell Proteomics. 2016 Mar;15(3):892-905.

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