Cart
sales@molnova.com
AUTEN-67
CAS No. 1783800-77-0
AUTEN-67( Autophagy Enhancer 67 | AUTEN67 )
Catalog No. M12684 CAS No. 1783800-77-0
A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameAUTEN-67
-
NoteResearch use only, not for human use.
-
Brief DescriptionA small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively.
-
DescriptionA small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14; at concentrations of 2, 10, and 100 uM, AUTEN-67 inhibits MTMR14 by nearly 3%, 25%, and 70%, respectively; shows no activity for CDC25B , other phosphatase, PTPN1; significantly increases autophagic flux in cell lines and in vivo models, promotes longevity and protects neurons from undergoing stress-induced cell death; also restores nesting behavior in a murine model of Alzheimer disease, without apparent side effects.
-
In Vitro——
-
In VivoAnimal Model:Alzheimer disease model (Mice expressing the human APP)Dosage:19 mg/kg, 3 times a week for 3 month Administration:Oral administration Result:Restored nesting behavior by around 30%.Decreased Amyloid β levels in the hemibrain of mice.
-
SynonymsAutophagy Enhancer 67 | AUTEN67
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorAutophagy
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1783800-77-0
-
Formula Weight474.45
-
Molecular FormulaC23H14N4O6S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1=CC=C2C(=C1)C(=O)C(=C(C2=O)N3C=NC4=CC=CC=C43)NS(=O)(=O)C5=CC=C(C=C5)[N+](=O)[O-]
-
Chemical NameN-(3-(1H-benzo[d]imidazol-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-nitrobenzenesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Papp D, et al. Autophagy. 2016;12(2):273-86.
2. Billes V, et al. J Huntingtons Dis. 2016 May 7;5(2):133-47.
molnova catalog
related products
-
A-867744
A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).
-
Amiodarone
Amiodarone (Cordarone) is an antiarrhythmic compound that induces pulmonary toxicity and inhibits ATP-sensitive potassium channels.Amiodarone has shown some antiviral activity in SARS-CoV-2-induced disease.
-
PHY34
PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM); disrupts lysosomal function, significantly inhibits the growth of cancer cell lines in hollow fibers.
