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Stafib-1
CAS No. 1688703-26-5
Stafib-1( Stafib 1 )
Catalog No. M12577 CAS No. 1688703-26-5
A potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameStafib-1
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
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DescriptionA potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a.
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In VitroStafib-1 is the first small molecule which inhibits the STAT5b SH2 domain with more than 50-fold selectivity over STAT5a.
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In Vivo——
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SynonymsStafib 1
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1688703-26-5
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Formula Weight602.429
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Molecular FormulaC26H24N2O11P2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (166.00 mM)
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SMILESO=C(NCC1=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C1)COC2=CC=C3C=C(C(NC4=CC=CC=C4)=O)C=CC3=C2
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Chemical Name4-((2-((6-(phenylcarbamoyl)naphthalen-2-yl)oxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Elumalai N, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4758-63.
2. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.
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