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CK-101
CAS No. 1660963-42-7
CK-101( RX-518 | RX518 | CK101 )
Catalog No. M12535 CAS No. 1660963-42-7
CK-101 (RX-518) is a novel potent, mutant-selective, irreversible, orally available EGFR inhibitor, overcomes T790M-mediated resistance in NSCLC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 107 | In Stock |
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| 5MG | 92 | In Stock |
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| 10MG | 147 | In Stock |
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| 25MG | 306 | In Stock |
|
| 50MG | 439 | In Stock |
|
| 100MG | 644 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCK-101
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NoteResearch use only, not for human use.
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Brief DescriptionCK-101 (RX-518) is a novel potent, mutant-selective, irreversible, orally available EGFR inhibitor, overcomes T790M-mediated resistance in NSCLC.
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DescriptionCK-101 (RX-518) is a novel potent, mutant-selective, irreversible, orally available EGFR inhibitor, overcomes T790M-mediated resistance in NSCLC; specifically targets the mutant forms of EGFR, including T790M, while exhibiting minimal activity toward WT EGFR; selectively inhibits cell proliferation of cell lines expressing both the activating (HCC827, IC50 <15 nM) and resistance mutations (NCI-H1975, IC50 <5 nM); significantly inhibits tumor growth in EGFR-mutated NSCLC tumor xenograft models, with no activity in WT EGFR tumor xenograft model.Lung Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsRX-518 | RX518 | CK101
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1660963-42-7
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Formula Weight530.58
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Molecular FormulaC29H28F2N6O2
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Purity>98% (HPLC)
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SolubilityDMSO : 125 mg/mL 235.60 mM; H2O : < 0.1 mg/mL
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SMILESC=CC(NC1=CC=CC(C2=CC=CC3=CN=C(NC4=CC=C(N5CCN(CCO)CC5)C(F)=C4F)N=C23)=C1)=O
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Chemical NameN-[3-[2-[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]anilino]quinazolin-8-yl]phenyl]prop-2-enamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Xiangping Qian, et al. Abstract 2078: CK-101 (RX518), a mutant-selective inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. DOI: 10.1158/1538-7445.AM2017-2078
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