Cart
sales@molnova.com
Home - Products - Endocrinology/Hormones - Opioid Receptor - Naltrexone

Naltrexone

CAS No. 16590-41-3

Naltrexone( —— )

Catalog No. M12531 CAS No. 16590-41-3

A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Naltrexone
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
  • Description
    A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).Alcoholism Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    Opioid Receptor
  • Research Area
    Neurological Disease
  • Indication
    Alcoholism

Chemical Information

  • CAS Number
    16590-41-3
  • Formula Weight
    341.4009
  • Molecular Formula
    C20H23NO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 31 mg/mL
  • SMILES
    C1CC1CN2CCC34C5C(=O)CCC3(C2CC6=C4C(=C(C=C6)O)O5)O
  • Chemical Name
    Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5α)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. 2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809. 3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Noscapine hydrochlor...

    A naturally occurring opium alkaloid that is a centrally acting antitussive agent.

  • [(pF)Phe4]Nociceptin...

    Highly potent and selective nociceptin/orphanin FQ receptor (OP4) agonist peptide (pKi = 10.68; pEC50 = 9.80). Displays > 8000-fold selectivity over δ, κ, and μ opioid receptors and has relatively long lasting pronociceptive, hypotensive, negative inotropic and feeding stimulation effects in vivo.

  • Salvinorin A

    Salvinorin A is a non-nitrogenous κ-opioid selective agonist.

Sign In Join Free