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Leelamine hydrochloride

CAS No. 16496-99-4

Leelamine hydrochloride( Dehydroabietylamine )

Catalog No. M12521 CAS No. 16496-99-4

Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Leelamine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR).
  • Description
    Leelamine hydrochloride (Dehydroabietylamine) is a novel inhibitor of androgen receptor (AR), inhibits castration-resistant prostate cancer cells; causes apoptosis and suppresses 22Rv1 xenograft growth in vivo; Leelamine mediates cancer cell death through inhibition of intracellular cholesterol transport.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Dehydroabietylamine
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor (AR)
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    16496-99-4
  • Formula Weight
    321.933
  • Molecular Formula
    C20H32ClN
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 25 mg/mL (77.66 mM)
  • SMILES
    CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)CN)C.Cl
  • Chemical Name
    1R,2,3,4,4aS,9,10,10aR-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine, monohydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Singh KB, et al. Mol Cancer Ther. 2018 Jul 20. pii: molcanther.0117.2018. 2. Gowda R, et al. Oncotarget. 2017 Apr 25;8(17):28260-28277. 3. Sehrawat A, et al. Mol Carcinog. 2017 Feb;56(2):337-348. 4. Kuzu OF, et al. Mol Cancer Ther. 2014 Jul;13(7):1690-703.
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