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GS-626510
CAS No. 1637770-13-8
GS-626510( GS-6510 | GS 6510 | GS 626510 )
Catalog No. M12471 CAS No. 1637770-13-8
GS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 267 | Get Quote |
|
| 50MG | 1071 | Get Quote |
|
| 100MG | 1674 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGS-626510
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NoteResearch use only, not for human use.
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Brief DescriptionGS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT.
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DescriptionGS-626510 (GS-6510, GS 6510, GS 626510) is a novel BET family bromodomains inhibitor with Kd of 0.5-2.8 nM for BRD2/3/4, and BRDT; shows weak affinity for CREBBP and EP300 (Ki=170 and 220 nM); potently inhibits growth of RKO cells with IC50 of 33 nM, decreases MYC levels; TRIM33 is required for the ability of GS-626510 to maximally down-regulate MYC.
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In Vitro——
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In Vivo——
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SynonymsGS-6510 | GS 6510 | GS 626510
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number1637770-13-8
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Formula Weight394.478
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Molecular FormulaC25H22N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (63.38 mMul)
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SMILESCC1=C(C2=CC(C3=C4C=CC=NC4=CC=C3C)=C5NC(C6CC6)=NC5=C2)C(C)=NO1
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Chemical Name4-(2-cyclopropyl-7-(6-methylquinolin-5-yl)-1H-benzo[d]imidazol-5-yl)-3,5-dimethylisoxazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shi X, et al. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4558-66.
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