JG-231( JG231 )

Catalog No. M12408 CAS No. 1627126-59-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

JG-231
Note

Research use only, not for human use.
Brief Description

JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM).
Description

JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively; reduces tumor burden in an MDA-MB-231 xenograft model (4 mg/kg, ip).
In Vitro

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In Vivo

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Synonyms

JG231
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

——
Indication

——

CAS Number

1627126-59-3
Formula Weight

619.45
Molecular Formula

C22H18BrCl2N3OS4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 2 mg/mL (3.23 mM)
SMILES

O=C1N(CC)/C(S/C1=C2SC3=CC(Cl)=CC=C3N/2C)=C/C4=[N+](CC5=CC=C(Br)S5)C=CS4.[Cl-]
Chemical Name

3-((5-bromothiophen-2-yl)methyl)-2-((Z)-((E)-5-(6-chloro-3-methylbenzo[d]thiazol-2(3H)-ylidene)-3-ethyl-4-oxothiazolidin-2-ylidene)methyl)thiazol-3-ium chloride

1. Shao H, et al. J Med Chem. 2018 Jul 13. doi: 10.1021/acs.jmedchem.8b00583.

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