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SNX-0723
CAS No. 1073969-18-2
SNX-0723( SNX 0723 | SNX0723 )
Catalog No. M10305 CAS No. 1073969-18-2
SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 312 | Get Quote |
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| 10MG | 500 | Get Quote |
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| 25MG | 807 | Get Quote |
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| 50MG | 1107 | Get Quote |
|
| 100MG | 1485 | Get Quote |
|
| 500MG | 2961 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSNX-0723
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NoteResearch use only, not for human use.
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Brief DescriptionSNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
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DescriptionSNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM; induces Hsp70 (IC50=31 nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4 nM), ribosomal protein s6 (pS6) (IC50=13 nM), and PERK (IC50=5.5 nM); shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties.
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In Vitro——
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In Vivo——
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SynonymsSNX 0723 | SNX0723
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP
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Research Area——
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Indication——
Chemical Information
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CAS Number1073969-18-2
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Formula Weight399.47
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Molecular FormulaC22H26FN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 20.83 mg/mL (52.15 mM)
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SMILESO=C(N)C1=C(N[C@@H]2COCC2)C=C(N3C=C(C)C4=C3CC(C)(C)CC4=O)C=C1F
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Chemical Name2-fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Putcha P, J Pharmacol Exp Ther. 2010 Mar;332(3):849-57.et al.
2. McFarland NR, et al. PLoS One. 2014 Jan 20;9(1):e86048.
3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42.
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