VR-23( VR23 )

Catalog No. M12402 CAS No. 1624602-30-7

COA

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HNMR

HPLC

MSDS

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Product Name

VR-23
Note

Research use only, not for human use.
Brief Description

A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).
Description

A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM); targets the β2 of the 20S proteasome catalytic subunit and structurally distinct from other known proteasome inhibitors and selectively kills cancer cells by apoptosis, with little effect on noncancerous cells.
In Vitro

VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to PS-341. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.
In Vivo

VR23 shows effective antitumor and antiangiogenic activities in mice.
Synonyms

VR23
Pathway

Proteasome/Ubiquitin
Target

Proteasome
Recptor

Caspase-likeproteasomes|Chymotrypsin-likeproteasomes|Trypsin-likeproteasomes
Research Area

Metabolic Disease
Indication

——

CAS Number

1624602-30-7
Formula Weight

477.8782
Molecular Formula

C19H16ClN5O6S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C32)CC1)(C4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)=O
Chemical Name

Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-

1. Pundir S, et al. Cancer Res. 2015 Oct 1;75(19):4164-75.

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