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MG-115
CAS No. 133407-86-0
MG-115( —— )
Catalog No. M33748 CAS No. 133407-86-0
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | Get Quote |
|
| 5MG | 93 | Get Quote |
|
| 10MG | 170 | Get Quote |
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| 25MG | 302 | Get Quote |
|
| 50MG | 449 | Get Quote |
|
| 100MG | 642 | Get Quote |
|
| 200MG | 888 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMG-115
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NoteResearch use only, not for human use.
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Brief DescriptionMG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively.
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DescriptionMG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.
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In VitroMG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells.MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates.Cell Viability Assay Cell Line:HepG2 cells Concentration:0.1, 1, 2, 5, 10 μM Incubation Time:24 hoursResult:Dose-dependently decreased cell viability.Inhibited the proteasomal activity, with an IC50 of 2?μM.
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In Vivo——
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Synonyms——
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number133407-86-0
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Formula Weight461.59
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Molecular FormulaC25H39N3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (216.64 mM; Ultrasonic (<60°C)
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SMILESCCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rock KL, et, al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9;78(5):761-71.?
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