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Home - Products - Proteasome/Ubiquitin - Proteasome - MG-115

MG-115

CAS No. 133407-86-0

MG-115( —— )

Catalog No. M33748 CAS No. 133407-86-0

MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 93 Get Quote
10MG 170 Get Quote
25MG 312 Get Quote
50MG 454 Get Quote
100MG 663 Get Quote
200MG 918 Get Quote
500MG Get Quote Get Quote
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Biological Information

  • Product Name
    MG-115
  • Note
    Research use only, not for human use.
  • Brief Description
    MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively.
  • Description
    MG-115 is a potent and reversible proteasome inhibitor, with Kis of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis.
  • In Vitro
    MG-115 (0.1-10 μM; 24 h) dose-dependently decreases the viability of HepG2 cells.MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK18 DNA condensates.Cell Viability Assay Cell Line:HepG2 cells Concentration:0.1, 1, 2, 5, 10 μM Incubation Time:24 hoursResult:Dose-dependently decreased cell viability.Inhibited the proteasomal activity, with an IC50 of 2?μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Proteasome
  • Recptor
    Proteasome
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    133407-86-0
  • Formula Weight
    461.59
  • Molecular Formula
    C25H39N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (216.64 mM; Ultrasonic (<60°C)
  • SMILES
    CCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Rock KL, et, al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9;78(5):761-71.?
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