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STX3451
CAS No. 1623785-58-9
STX3451( STX-3451 | STX 3451 )
Catalog No. M12399 CAS No. 1623785-58-9
A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSTX3451
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NoteResearch use only, not for human use.
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Brief DescriptionA non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor.
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DescriptionA non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM; induces apoptosis in human malignant peripheral nerve sheath tumour (MPNST) cell lines, inhibits both PI3 kinase and mTOR signalling pathways, selectively kills MPNST-derived cells, but also halts growth of other tumour-derived NF1 cell lines.
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In Vitro——
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In Vivo——
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SynonymsSTX-3451 | STX 3451
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetMicrotubule/Tubulin
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RecptorMicrotubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number1623785-58-9
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Formula Weight487.365
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Molecular FormulaC19H23BrN2O6S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-(3-Bromo-4,5-dimethoxybenzyl)-7-methoxy-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Shen YC, et al. Br J Cancer. 2015 Oct 20;113(8):1158-67.
2. Dohle W, et al. ChemMedChem. 2014 Aug;9(8):1783-93.
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