Cart
sales@molnova.com
STX3451
CAS No. 1623785-58-9
STX3451( STX-3451 | STX 3451 )
Catalog No. M12399 CAS No. 1623785-58-9
A non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSTX3451
-
NoteResearch use only, not for human use.
-
Brief DescriptionA non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor.
-
DescriptionA non-steroidal sulphamate analogue of 2-methoxyoestradiol (2ME2) and microtubule disruptor, shows anti-proliferative activity against NCI 60 cell lines with mean GI50 of 50 nM; induces apoptosis in human malignant peripheral nerve sheath tumour (MPNST) cell lines, inhibits both PI3 kinase and mTOR signalling pathways, selectively kills MPNST-derived cells, but also halts growth of other tumour-derived NF1 cell lines.
-
In Vitro——
-
In Vivo——
-
SynonymsSTX-3451 | STX 3451
-
PathwayCytoskeleton/Cell Adhesion Molecules
-
TargetMicrotubule/Tubulin
-
RecptorMicrotubule/Tubulin
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1623785-58-9
-
Formula Weight487.365
-
Molecular FormulaC19H23BrN2O6S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name2-(3-Bromo-4,5-dimethoxybenzyl)-7-methoxy-6-sulfamoyloxy-1,2,3,4-tetrahydroisoquinoline
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Shen YC, et al. Br J Cancer. 2015 Oct 20;113(8):1158-67.
2. Dohle W, et al. ChemMedChem. 2014 Aug;9(8):1783-93.
molnova catalog
related products
-
Fosbretabulin disodi...
A derivative of combretastatin that acts as a microtubule destabilising agent.
-
Oxymatrine
Oxymatrine is an alkaloid isolated from Sophora flavescens, used as the antibiotic. It is a traditional Chinese medicine used in the treatment against hepatitis B virus.
-
Taccalonolide A
Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities.?Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis.
