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EPZ-015866
CAS No. 1616391-87-7
EPZ-015866( GSK-591 | GSK-3203591 )
Catalog No. M12360 CAS No. 1616391-87-7
EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 103 | In Stock |
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| 2MG | 53 | In Stock |
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| 5MG | 97 | In Stock |
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| 10MG | 140 | In Stock |
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| 25MG | 282 | In Stock |
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| 50MG | 417 | In Stock |
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| 100MG | 585 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEPZ-015866
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NoteResearch use only, not for human use.
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Brief DescriptionEPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.
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DescriptionEPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM; shows excellent selectivity against other PMT enzymes observed with EPZ015666; inhibits the proliferation of Z-138 cells with IC50 of 62 nM.
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In VitroGSK591 (5 μM; MCF7, T47D, and MCF10A cells) treatment suppresses breast cancer stem cells (BCSCs) proliferation and self-renewal. GSK591 reduces BCSCs numbers in vitro. Cell Proliferation Assay Cell Line:MCF7, T47D, and MCF10A cells Concentration:5 μM Incubation Time:Result:Suppressed BCSCs proliferation and self-renewal.
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In Vivo——
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SynonymsGSK-591 | GSK-3203591
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorPRMT5
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1616391-87-7
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Formula Weight380.4833
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Molecular FormulaC22H28N4O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4CCC4)=NC=C3
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Chemical Name4-Pyridinecarboxamide, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Duncan KW, et al. ACS Med Chem Lett. 2015 Dec 2;7(2):162-6.
2.?Gerhart SV, et al. Sci Rep. 2018 Jun 26;8(1):9711.
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